Principal Scientist (ADME)

About This Role

This Principal Scientist (ADME) role focuses on developing and executing advanced in vitro ADME assays to support accelerated drug discovery for a biotech company. The position involves delivering high-quality ADME data for lead optimization within a high-throughput environment. Key responsibilities include assay development, automation, and data interpretation.

Responsibilities

• Develop, optimize, and validate high-throughput in vitro ADME assays covering solubility, permeability, protein binding, metabolic stability, and enzyme inhibition/induction
• Utilize automated liquid handling systems for assay automation and screening
• Perform and troubleshoot mass spectrometry analyses, including method development
• Manage sample preparation and conduct data analysis to calculate pharmacokinetic parameters
• Communicate results and provide recommendations to cross-functional project teams
• Maintain laboratory documentation and ensure compliance with quality and safety standards

Requirements

• Ph.D. (2+ years industry experience) or Master's degree (5+ years industry experience) in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or related field
• Hands-on experience with LC-MS or acoustic mass spectrometry in high-throughput settings
• Proven ability in automated in vitro ADME assay development
• Strong knowledge of drug metabolism pathways and DMPK
• Familiarity with ADME prediction and data visualization tools

Qualifications

• Ph.D. or Master's degree in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or related field
• 2+ years industry experience with Ph.D. or 5+ years industry experience with Master's degree in relevant field

Nice to Have

• Experience with laboratory automation and electronic data capture systems
• Programming skills (e.g., Python, R) and data visualization expertise
• Experience with clinical sample handling and CRO environments

Skills

* Required skills

Benefits