Research Scientist, Cell Biology – T Cell Biology (MD/ PhD)

About This Role

Lead characterization studies to evaluate product efficacy and safety for T-cell biology products. Design and perform experiments, analyze results, and communicate findings in team meetings.

Responsibilities

• Execute cell-based functional and biochemical assays to select candidate molecules for clinical development or support combination strategies to enhance T-cell product potency and safety
• Design experiments to address basic tumor immunology aspects related to the immunosuppressive tumor microenvironment
• Genetically/biochemically manipulate T-cells and evaluate impact on T-cell function
• Analyze, organize and communicate results at different research and cross-functional meetings
• Plan and effectively execute experiments based on strategy, project timelines and goals
• Analyze and present scientific results to project teams and cross-functional audiences
• Document experimental results to enable subsequent clinical studies and patent applications
• Serve as a core team member or leader on a project team
• Work effectively with other functions (Process Development, Translational Medicine, Clinical Development) to ensure alignment
• Coordinate tasks across multiple projects, demonstrating prioritization and planning

Requirements

• Advanced scientific degree (MD, PharmD, PhD) OR Master’s Degree and 6+ years of scientific experience
• Experience designing and developing primary immune cell assays using key immune cell populations
• Hands-on expertise in T-cell functional characterization assays including in vitro cytotoxicity, proliferation, cytokine/chemokine measurements, cell signaling, activation, differentiation and exhaustion
• Proficient in cell culture aseptic technique
• Proficient in multi-parameter flow cytometry (panel design, sample acquisition, data processing) and data analysis (FACSDiva, FlowJo, GraphPad Prism, Excel)
• Experience with MSD/ELISA and/or Luminex

Qualifications

• Advanced scientific degree (MD, PharmD, PhD) OR Master’s Degree and 6+ years of scientific experience
• 6+ years of scientific experience with a Master's degree, or advanced scientific degree (MD, PharmD, PhD)

Nice to Have

• Ph.D. degree in biology-related field (immunology, cellular and/or tumor biology or a closely related field)
• Strong background in cancer immunotherapy and human immunology
• Experience working with engineered T cells strongly preferred
• Demonstrated independence in experimental design, data analysis, interpretation, and presentation
• Experience using both written and verbal communication, including presentations, to communicate results to a diverse cross-functional audience
• Strong organizational and record keeping skills

Skills

* Required skills