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Conduct independent and collaborative research in the Kawasumi Lab focusing on skin cancer biology and epigenetics, elucidating molecular mechanisms of UV-induced DNA damage responses and genetic/epigenetic changes.
Responsibilities
- Conduct independent and collaborative research projects in the Kawasumi Lab primarily on skin cancer biology and skin cancer epigenetics
- Investigate genomic and epigenomic abnormalities in skin cancer and how to modulate DNA damage responses or epigenetic changes to inhibit skin cancer
- Study UV-induced DNA damage responses, UV-mediated skin diseases (skin cancer and lupus), skin disease epigenetics, exosomes, and 3D skin models
- Elucidate molecular mechanisms by which cells sense UV-induced DNA lesions (CPD and 6-4PP) and activate biological processes
- Dissect the molecular mechanisms by which genetic/epigenetic changes occur during cancer evolution, caffeine treatment, and UV-induced DNA damage and lupus development
- Document research data, identify technical problems, and propose solutions
- Mentor junior lab members, providing technical and intellectual guidance and troubleshooting
- Develop approaches and protocols while maintaining quality and cost effectiveness
- Train junior scientists in specific, standardized techniques and instrumentation
- Contribute to the preparation of oral/poster presentations, manuscripts, and grant applications
Requirements
- Extensive, direct, hands-on experience with molecular and cellular assays
- Experience with mouse studies
- Next-generation sequencing data analysis
- Bioinformatics and statistical analysis
- Scientific writing
- Presenting data to various groups
- Highly motivated with a track record of productive research (publication/presentations)
- Ability to discuss with PI and collaborators, prioritize tasks, and meet deadlines
Qualifications
- PhD in Biological Sciences or relevant field
Skills
Statistical analysis
*
Flow cytometry
*
Cell culture
*
Bioinformatics
*
Proteomics
*
Next generation sequencing
*
DNA Replication Track Analysis
*
Western Blot Analysis
*
Chromatin Immunoprecipitation (ChIP)
*
Genome Editing
*
Epigenome Editing
*
Small-Molecule Screening
*
Mouse Genetic Models
*
Patient-Derived Xenograft (PDX) Models
*
* Required skills
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