Senior Scientist

About This Role

Lead protein engineering efforts to expand biotherapeutic possibilities for patients with serious diseases. This role involves designing, engineering, and preclinical characterization of biomolecular scaffolds, working within a multidisciplinary team.

Responsibilities

• Construct recombinant systems encoding protein variants and combinatorial protein libraries
• Conceptualize, construct, qualify, and implement high throughput screening platforms
• Conduct precision protein engineering to achieve specified design objectives
• Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs
• Develop, qualify, and deploy quantitative functional assays to characterize protein performance in vitro
• Assess therapeutic candidate performance using in vivo models
• Contribute to collaborative prioritization and decision making on prospective discovery and development programs
• Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis
• Participate in cross-disciplinary mentoring and training within the RDL NH team
• Present scientific results to the RDL NH team, Insmed research department, and external scientific community

Requirements

• Deep technical understanding of, and hands-on experience with, molecular biology, recombinant DNA technology, protein mutagenesis, and protein biochemistry
• Expertise with recombinant protein expression and purification
• Expertise with routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, ELISA
• Experience with protein-protein binding analysis
• Proven track record in experimental methods development, including experimental design, execution, and evaluation

Qualifications

• PhD in biochemistry, molecular biology, bioengineering or related field, or MS degree in biochemistry, molecular biology, bioengineering or related field
• 5+ years of experience with PhD or 9+ years of experience with MS in biochemistry, molecular biology, bioengineering or related field

Nice to Have

• Experience with enzyme analysis
• Experience in high throughput functional screen development for protein libraries
• Experience with lab automation
• Experience with next-generation sequencing

Skills

* Required skills

Benefits