Science Team Lead - Epigenetic Reprogramming

About This Role

Lead an innovative research program at e184, focusing on advanced epigenetic editing technologies for therapeutic applications. This role involves guiding scientific planning, supervising project execution, and contributing directly to experimental design and execution.

Responsibilities

• Lead a focused research team of 4-6 scientists reporting directly to the CSO
• Design and personally conduct experiments in DNA methylation editor optimization and validation
• Develop guide RNA libraries targeting chromatin regulatory regions
• Establish protocols for targeted methylation editing with persistence validation through cell divisions
• Create delivery strategies for enhanced efficiency in challenging cell types
• Execute single and multiplex editing approaches with maintained specificity across targets
• Drive progression from cell culture proof-of-concept to functional validation in mammalian models
• Define research approaches and priorities aligned with company objectives
• Drive scientific output, IP development, and milestone achievement within established timelines

Requirements

• PhD in Molecular Biology, Epigenetics, Developmental Biology, or related field
• Minimum 5 years postdoctoral or industry experience in epigenetic editing, chromatin modification, or CRISPR-based technologies
• Proven expertise developing DNA methylation editors including fusion protein design and optimization
• Hands-on experience with guide RNA design and validation for chromatin targets
• Advanced skills in DNA methylation and chromatin modification analysis
• Knowledge of chromatin biology, gene regulation, and epigenetic inheritance mechanisms
• Experience leading research teams while maintaining significant hands-on involvement

Qualifications

• PhD in Molecular Biology, Epigenetics, Developmental Biology, or related field
• Minimum 5 years postdoctoral or industry experience in epigenetic editing, chromatin modification, or CRISPR-based technologies

Nice to Have

• Experience with allele-specific epigenetic editing approaches
• Track record of integrating innovative experimental and computational approaches in epigenetic editing with publications in high-impact journals and experience in IP development
• Familiarity with mammalian reproduction models and developmental biology applications

Skills

* Required skills

Benefits