Principal Scientist, New Biological Entities PK/BA Group

About This Role

This Principal Scientist role leads drug discovery efforts for New Biological Entities (NBE) by representing the pharmacokinetic discipline on multi-disciplinary project teams and integrating PK and biomeasure considerations into strategy. The role focuses on identifying strategic scientific opportunities within NBE preclinical research and enhancing decision-making through innovative concepts and technology goals.

Responsibilities

• Independently design and perform scientific experiments, developing new methodologies and protocols that contribute to core group goals and reflect expert knowledge
• Direct and oversee experimental design and results of staff in a matrixed environment, supporting Oncology, Immunology, and Cardiometabolic therapeutic areas
• Define R&D team goals and collaborate with scientists within and outside the functional area; assume departmental responsibility as representative on multiple project teams as DDS Lead
• Prepare clear technical reports, external publications, and oral presentations, communicating results to senior-level management in the context of overall project goals
• Demonstrate expertise in a specific project-relevant area or technology, providing guidance to advance projects or evaluate new technologies and concepts
• Effectively collaborate with scientists within and outside the functional area (e.g., therapeutic area biologists, protein engineering scientists)
• Develop broad knowledge in the field of expertise, including interpreting current literature relevant to R&D projects
• Actively support recruitment, mentorship, and development of scientific staff
• Comply with all applicable regulations, ensuring work performed is safe and compliant, and maintaining proper records
• Contribute to departmental administration and demonstrate fiscal responsibility with respect to experiment costs, technology, external collaborations, and travel

Requirements

• Ph.D. with 5+ years experience in pharmacokinetics, pharmacology, biology, or pharmaceutical sciences
• 1-3 years experience leading employees and projects
• Broad knowledge of drug discovery
• Strong practical knowledge of NBE pharmacokinetic principles including design and interpretation of PK studies, ligand binding assays, and biodistribution concepts
• Ability to communicate effectively both orally and in writing in an interdisciplinary environment

Qualifications

• Ph.D. from an accredited institution, or equivalent, in a related field (pharmacokinetics, pharmacology, biology, pharmaceutical sciences)
• Five-plus (5+) years of experience in a related field or equivalent (pharmacokinetics, pharmacology, biology, pharmaceutical sciences)

Nice to Have

• Research experience in oncology, immunology, and/or cardio-metabolic diseases
• Preclinical PK/PD modeling experience

Benefits