Principal Scientist - Cancer Early Detection
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Upload Your ResumeAbout This Role
Lead the Cancer Early Detection Team, focusing on building early warning systems for cancer using arrays of blood- and urine-based biomarkers and machine learning.
Responsibilities
- Lead a cutting-edge cancer biomarkers group with the goal of detecting cancer at its earliest stages
- Contribute highly practical and readily translatable pan-cancer screening/early detection, diagnostic, prevention and therapeutic ideas
- Quantify and track cancer biomarkers, including CTCs, cfDNA, serum, plasma, and urine proteins, RNA, metabolites, driver-gene mutations, epigenetic modifications
- Collaborate with ICR's Biomarkers Team to perform molecular and cellular cancer prevention screening assays, under a personalized medicine paradigm
Requirements
- Current and in-depth knowledge of pan-cancer: screening, early detection, biomarkers, diagnostic prediction, genetics, prevention, and chemical and vaccine-therapeutics (practical and experimental)
- Programming experience in R and Python
- Solid grasp of biostatistics, especially probability theory
- Experience with prediction modeling and machine learning, including experience using proper scoring rules
- Ability to work in the United States without sponsorship
Qualifications
- A PhD, MD or both
- At least 10 years of cancer research experience, preferably in early detection and biomarkers
Nice to Have
- Expert knowledge and understanding of worldwide cancer biomarker and detection assay development pipelines
- Experience with cell-based assays, immunofluorescent microscopy, qPCR, flow cytometry, single-cell genomics, RNAseq, cell culture, organoid culture, Illumina NextSeq 550, DNA methylation sequencing, ddPCR, Luminex, clinical chemistry instrumentation, Kryptor, Access 2, robotic liquid handling (e.g. Tecan), Vortex, and DepArray
- Experience with protein, RNA, and small metabolite cancer biomarker analysis
Skills
* Required skills
About BioSpace
Lilly is a global healthcare leader headquartered in Indianapolis, Indiana, specializing in discovering and bringing life-changing medicines to patients worldwide. They are investing over $1 billion to create a new state-of-the-art manufacturing site in Concord, NC, focusing on parenteral medication...