Director - Immunology Research

About This Role

This role involves spearheading research efforts focused on immune aging and rejuvenation to identify and develop novel interventions. The Director will drive cutting-edge research using various modalities to restore immune homeostasis, mitigate inflammaging, and improve organ function. This position offers the opportunity to build and manage a research team and provide cross-functional leadership.

Responsibilities

• Design and execute preclinical studies to investigate mechanisms underlying immune senescence, including age-related hematopoietic stem cell dysfunction, telomere attrition, senescence-associated phenotypes, and T-cell exhaustion
• Develop rejuvenation/reprogramming strategies to revitalize hemopoietic and non-immune, parenchymal cells of interest in immune and age-related disorders
• Utilize advanced techniques in cytometry, 'omics and hi-dimensional datasets to identify targetable nodes for intervention
• Use appropriate in vitro, in vivo and ex vivo models to assess immune aging phenotypes of interest
• Collaborate with stakeholders in Immunology and other therapeutic areas to cross-functionally lead and develop research findings into future clinical candidates
• Prepare and present research findings at internal meetings, scientific conferences, and in peer-reviewed publications
• Stay abreast of emerging advances in the field to inform strategic decisions and help assess external opportunities as needed
• Contribute to IP filings, and regulatory documentation as needed
• Recruit and train a small team to scale research efforts

Requirements

• PhD in Immunology, Cell Biology, Developmental Biology, or a related field
• Postdoctoral experience in aging biology or rejuvenation
• 5+ years of hands-on research experience in academia, biotech, or pharma related to immune aging/senescence research

Qualifications

• PhD in Immunology, Cell Biology, Developmental Biology, or a related field
• 5+ years of hands-on research experience in academia, biotech, or pharma, with a proven track record related to immune aging/senescence research

Nice to Have

• Demonstrated expertise in molecular mechanisms of immune senescence, including inflammaging, stem cell exhaustion, and therapeutic interventions
• Familiarity with landscape of immune aging research activities
• Strong publication record in high-impact journals with first- or senior-author contributions
• Proficiency in experimental design, data analysis and statistical methods
• Excellent communication skills
• Experience with in vivo models of aging (e.g., progeroid mice, humanized models) and translational strategies for rejuvenation therapies
• Advanced knowledge of stem cell rejuvenation techniques, epigenetic reprogramming and delivery systems
• Prior experience leading a cross-functional team and/or managing others
• Understanding of the unique regulatory hurdles in regeneration and aging-related therapeutics

Skills

* Required skills

Benefits