Associate Principal Scientist, Mass Spectrometry

About This Role

This role involves expanding treatment possibilities for patients with serious diseases by applying advanced mass spectrometry to characterize proteomic and metabolomic changes, identifying protein-based biomarkers, and contributing to the understanding of drug effects.

Responsibilities

• Develop, optimize, and implement advanced mass spectrometry workflows (DDA and DIA) to screen for and identify protein-based biomarkers associated with therapeutic activity
• Design and execute quantitative mass spectrometry experiments to measure low-abundance proteins in complex biological matrices (plasma, tissues, CSF)
• Design and conduct experiments to identify and characterize changes in the proteome or metabolome following inhibitor or therapeutic treatment of relevant biological samples
• Apply bioinformatics and data analysis tools to interpret complex datasets and identify relevant proteins, metabolites, and potential biomarkers
• Collaborate closely with cross-functional stakeholders to ensure timely delivery of high-quality data aligned with project objectives
• Prepare and present research findings at internal meetings and external scientific conferences and contribute to the preparation of manuscripts and scientific publications
• Stay current with emerging advances in mass spectrometry technologies and methodologies, particularly as applied to proteomics, metabolomics, and biomarker discovery in drug research

Requirements

• PhD in Chemistry, Biochemistry, or a related scientific discipline with strong emphasis on mass spectrometry–based proteomics, metabolomics, and protein quantification
• 10+ years of hands-on industry experience applying advanced mass spectrometry techniques in proteomics and protein quantification
• Demonstrated experience with LC–MS system operation, maintenance, and troubleshooting
• Strong understanding of cellular biology and the impact of protein inhibition on proteomic and metabolic pathways
• Proven ability to analyze, interpret, and communicate complex scientific data effectively
• Excellent written and verbal communication skills, with experience in scientific documentation and publication
• Strong work ethic, self-motivation, and a collaborative, team-oriented mindset
• Commitment to strict adherence to environmental, health, and safety (EHS) guidelines

Qualifications

• PhD in Chemistry, Biochemistry, or a related scientific discipline
• 10+ years of hands-on industry experience applying advanced mass spectrometry techniques in proteomics and protein quantification

Skills

* Required skills

Benefits